反応 #2298637

反応方程式

4-hydroxybenzaldehyde

K2CO3

2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline

→

title compound

収率 72.0%

4-[[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]benzaldehyde

収率 72.0%

溶媒

DMF

EtOAc

反応条件

後処理

1. 1
   workup.STIRRINGstirred further for 90 minutes at the same temperature
2. 2
   洗浄washed with aqueous Na2CO3 solution (3×50 ml)
3. 3
   乾燥with brine, dried over anhydrous Na2SO4
4. 4
   濃縮concentrated

実験手順

A mixture of 4-hydroxybenzaldehyde (3.21 g, 26.3 mmol and K2CO3 (3.64 g, 26.3 mmol) in dry DMF (50 ml) was stirred for 15 min at 30° C. To the above stirred mixture a solution of 2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline (5.0 g, 24.0 mmol) was added and stirred further for 90 minutes at the same temperature. The reaction mixture was diluted with EtOAc (200 ml), washed with aqueous Na2CO3 solution (3×50 ml) and then with brine, dried over anhydrous Na2SO4 and concentrated to yield the title compound (5.08 g, 72%).

出典