反応 #2298636

ord-cd6a191cb2194071a09074e5ba49edf2

反応方程式

CCc1nc2ccccc2c(=O)[nH]1
2-ethyl-4-oxo-3,4-dihydroquinazoline
O=Cc1ccc(OCCBr)cc1
4-(2-bromoethoxy)benzaldehyde
O=C([O-])[O-].[K+].[K+]
K2CO3
CCc1nc2ccccc2c(=O)n1CCOc1ccc(C=O)cc1
title compound
収率 27.0%
CCc1nc2ccccc2c(=O)n1CCOc1ccc(C=O)cc1
4-[2-[2-Ethyl-4-oxo-3,4-dihydro-3-quinazolinyl]ethoxy]benzaldehyde
収率 27.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他that described in preparation 1

実験手順

The title compound (5.0 g, 27%) was prepared from 2-ethyl-4-oxo-3,4-dihydroquinazoline (9.2 g, 57.5 mmol) and 4-(2-bromoethoxy)benzaldehyde (14.5 g, 69.0 mmol) in the presence of K2CO3 (14.6 g, 115.0 mmol) as base, by a similar procedure to that described in preparation 1.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: USRE039266E1uspto-grants-2006_09