反応 #2298635

ord-f6ad941d19cc4e868a5b487eb1675f8f

反応方程式

Cc1nc2ccccc2c(=O)[nH]1
2-methyl-4-oxo-3,4-dihydroquinazoline
O=Cc1ccc(OCCBr)cc1
4-[2-bromoethoxy]benzaldehyde
O=C([O-])[O-].[K+].[K+]
K2CO3
Cc1nc2ccccc2c(=O)n1CCOc1ccc(C=O)cc1
title compound
収率 39.0%
Cc1nc2ccccc2c(=O)n1CCOc1ccc(C=O)cc1
4-[2-[2-Methyl-4-oxo-3,4-dihydro-3-quinazolinyl]ethoxy]benzaldehyde
収率 39.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他preparation 1

実験手順

The title compound (0.6 g, 39%) was prepared from 2-methyl-4-oxo-3,4-dihydroquinazoline (0.8 g, 5 mmol) and 4-[2-bromoethoxy]benzaldehyde (1.37 g, 6 mmol) in the presence of K2CO3 (1.38 g, 10.0 mmol) as base, by a similar procedure to that described is preparation 1.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: USRE039266E1uspto-grants-2006_09