反応 #2298634

ord-8dbb29c41e43416fa2f73df7b71b06c9

反応方程式

O=c1[nH]cnc2ccccc12
4-oxo-3,4-dihydroquinazoline
O=Cc1ccc(OCCBr)cc1
4-[2-bromoethoxy]benzaldehyde
O=C([O-])[O-].[K+].[K+]
K2CO3
O=Cc1ccc(OCCn2cnc3ccccc3c2=O)cc1
title compound
収率 73.0%
O=Cc1ccc(OCCn2cnc3ccccc3c2=O)cc1
4-[2-[4-Oxo-3,4-dihydro-3-quinazolinyl]ethoxy]benzaldehyde
収率 73.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他that described in preparation 1

実験手順

The title compound (1.5 g 73%) was prepared from 4-oxo-3,4-dihydroquinazoline (1.03 g, 7.05 mmol) and 4-[2-bromoethoxy]benzaldehyde (1.77 g, 7.7 mmol) in the presence of K2CO3 (2.0 g, 14.5 mmol) as base, by a similar procedure to that described in preparation 1.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: USRE039266E1uspto-grants-2006_09