反応 #2298627

反応方程式

6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine

6-(3-Thienyl)-4-chlorothieno[3,2-d]pyrimidine

hydrazine monohydrate

→

(6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride

収率 66.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 1 hour
3. 3
   ろ過the solid product was collected by vacuum filtration

実験手順

A suspension of 6-(3-thienyl)-4-chlorothieno[3,2-d]pyrimidine (220, 65 mg, 0.26 mmol) and hydrazine monohydrate (0.1 mL, 2.1 mmol) in ethanol (1 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl) hydrazine hydrochloride (48 mg, 66% yield) as a white solid.

出典