反応 #2298623

反応方程式

(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

(7-Bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

3-pyridinecarboxaldehyde

→

3-pyridinecarboxaldehyde(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazone

収率 81.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 4 hours
3. 3
   ろ過the solid product was collected by vacuum filtration

実験手順

A suspension of (7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (168, 29 mg, 0.12 mmol) and 3-pyridinecarboxaldehyde (18 mg, 0.17 mmol) in ethanol (2 mL) was heated at reflux for 4 hours. After cooling to room temperature, the solid product was collected by vacuum filtration to yield 3-pyridinecarboxaldehyde(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazone (32 mg, 81% yield) as a pale yellow solid.

出典