反応 #2298470

反応方程式

methyl 2,3-dihydro-4-methyl-2-thioxothieno[3,4-d]imidazole-6-carboxylate

ethyl iodide

NaOH

→

Methyl 2-ethylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   workup.ADDITIONthere was added water
3. 3
   その他to give crystals
4. 4
   その他Recrystallization from ethyl acetate

実験手順

A mixture of methyl 2,3-dihydro-4-methyl-2-thioxothieno[3,4-d]imidazole-6-carboxylate (1.1 g), ethyl iodide (0.75 g), 2N NaOH (2.4 ml) and methanol (30 ml) was stirred at room temperature for 3 hours. The reaction mixture was concentrated, and there was added water to give crystals. Recrystallization from ethyl acetate--hexane afforded colorless prisms (1.0 g, 83%), m.p. 159°-160° C.

出典