反応 #2292389

反応方程式

6-chloro-3-(7-methylbenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine

xantphos

potassium carbonate

3,4-dimethoxyaniline

→

yellow solid

収率 116.8%

N-(3,4-dimethoxyphenyl)-3-(7-methylbenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-amine

収率 116.8%

溶媒

dioxane

反応条件

後処理

1. 1
   その他Purification by column chromatography
2. 2
   洗浄2% methanol in dichloromethane elution

実験手順

To a solution of 6-chloro-3-(7-methylbenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine (50 mg, 0.167 mmol, 1.0 equiv), xantphos (19 mg, 0.0334 mmol, 0.2 equiv), palladium acetate (4 mg, 0.0167 mmol, 0.1 equiv), and potassium carbonate (461 mg, 3.34 mmol, 20 equiv) in dioxane (5.0 mL) was added 3,4-dimethoxyaniline (21 mg, 0.184 mmol, 1.1 equiv) and heated to 110° C. for 2 h. Purification by column chromatography using 2% methanol in dichloromethane elution gave 40 mg, 0.195 mmol of the yellow solid, 58%.

出典