反応 #2290372

反応方程式

2-amino-4,6-dimethylnicotinonitrile

chloroacetaldehyde

→

title compound

収率 75.0%

5,7-dimethylimidazo[1,2-a]pyridine-8-carbonitrile

収率 75.0%

溶媒

water

反応条件

後処理

1. 1
   その他On completion, it was quenched by 1N NaOH till pH 8
2. 2
   その他Solid precipitated
3. 3
   ろ過was filtered
4. 4
   その他vacuum dried

実験手順

To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).

出典