反応 #2286363

反応方程式

tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

potassium carbonate

dimethyl 1-diazo-2-oxopropylphos-phonate

→

tert-Butyl 4-(4-ethynyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   抽出After aqueous work-up, the mixture was extracted with ethyl acetate
2. 2
   乾燥the extracts were dried with sodium sulphate
3. 3
   濃縮the solvent was concentrated under reduced pressure
4. 4
   その他The residue was purified chromatographically

実験手順

Under argon, tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (600 mg) was dissolved in methanol, and potassium carbonate (839 mg) and dimethyl 1-diazo-2-oxopropylphos-phonate (786 mg) were added. The mixture was stirred at room temperature for 3 hours. After aqueous work-up, the mixture was extracted with ethyl acetate, the extracts were dried with sodium sulphate and the solvent was concentrated under reduced pressure. The residue was purified chromatographically. This gave tert-butyl 4-(4-ethynyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (493 mg).

出典