反応 #2286357

反応方程式

hydrogen chloride

tert-butyl 4-[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

→

4-[4-(Cyclohexylacetyl)-1,3-thiazol-2-yl]piperidinium chloride

溶媒

dioxane

diethyl ether

反応条件

後処理

1. 1
   温度slowly warmed to room temperature
2. 2
   workup.STIRRINGAfter stirring overnight
3. 3
   その他excess acid and the solvent were removed under reduced pressure

実験手順

Under argon and at 0° C., a solution of hydrogen chloride in dioxane (4M, 1 ml) was added to a solution of tert-butyl 4-[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (5.0 g) in diethyl ether (1 ml). The mixture was stirred at 0° C. and then slowly warmed to room temperature. After stirring overnight, excess acid and the solvent were removed under reduced pressure. This gave 4[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidinium chloride (315 mg).

出典