反応 #2275735

ord-558d628ec3ee49fdbda04e7587eb0fb0

反応方程式

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(Oc2ccncn2)CC1
4-(pyrimidin-4-yloxy)-cyclohexanone
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(Oc3ccncn3)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(Oc3ccncn3)CC2)C1
N-({1-[4-(Pyrimidin-4-yloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compounds were prepared as white solids from the reductive amination of 4-(pyrimidin-4-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08324186B2uspto-grants-2012_12