反応 #2275717

反応方程式

[(3-hydroxy-pyridine-2-carbonyl)-amino]-acetic acid tert-butyl ester

TFA

→

desired compound

収率 99.0%

[(3-Hydroxy-pyridine-2-carbonyl)-amino]-acetic acid

収率 99.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   濃縮then concentrated under reduced pressure

実験手順

To a solution of [(3-hydroxy-pyridine-2-carbonyl)-amino]-acetic acid tert-butyl ester, 29, (0.070 g, 0.277 mmol) in CH2Cl2 (4 mL) is added TFA (1 mL). The resulting solution is stirred for 5 hours then concentrated under reduced pressure to afford 0.054 g (99% yield) of the desired compound as a colorless solid. 1H NMR (400 MHz, MeOD) δ ppm 8.09 (1H, d, J=3.3 Hz), 7.36-7.59 (2H, m), 4.08 (2H, s). HPLC-MS: m/z 197 [M+H]+.

出典