反応 #2275704

反応方程式

[(4′-chloro-3-methoxy-biphenyl-4-carbonyl)-amino]-acetic acid ethyl ester

BBr3

→

desired product

収率 41.0%

[(4′-chloro-3-hydroxy-biphenyl-4-carbonyl)-amino]-acetic acid

収率 41.0%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   その他is quenched with H2O (0.5 mL)
2. 2
   抽出The mixture is extracted with EtOAc (×2)
3. 3
   その他the organic phase separated
4. 4
   乾燥dried (MgSO4)
5. 5
   ろ過filtered
6. 6
   濃縮concentrated under reduced pressure
7. 7
   その他The crude material is purified by preparative HPLC

実験手順

To a solution of [(4′-chloro-3-methoxy-biphenyl-4-carbonyl)-amino]-acetic acid ethyl ester (0.053 g, 0.152 mmol) in CH2Cl2 (2 mL) at room temperature under nitrogen is added BBr3 (1.52 ml of a 1M solution in CH2Cl2, 1.52 mmol) dropwise. The resulting mixture is stirred for 3 days after which time the reaction is quenched with H2O (0.5 mL) then acidified to pH 1 with conc. HCl. The mixture is extracted with EtOAc (×2), the organic phase separated, dried (MgSO4), filtered and concentrated under reduced pressure. The crude material is purified by preparative HPLC to afford 0.019 g (41% yield) of the desired product as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.41 (1H, s), 9.19 (1H, s), 7.96 (1H, d, J=8.3 Hz), 7.74 (2H, d, J=8.7 Hz), 7.54 (2H, d, J=8.7 Hz), 7.21 (1H, d, J=1.7 Hz), 7.26 (1H, dd, J=8.3, 1.8 Hz), 3.99 (2H, d, J=5.5 Hz). HPLC-MS: m/z 306 [M+H]+.

出典