反応 #2275685

反応方程式

glycidol

ethanolamine

→

syrup

収率 72.0%

N-(Hydroxyethyl)-Amino-2,3-propanediol

収率 72.0%

反応条件

後処理

1. 1
   workup.ADDITIONOnce addition
2. 2
   workup.DISTILLATIONThe product was then distilled (Ethanolamine first
3. 3
   workup.DISTILLATIONdistilled at 60° C. at 1 Torr
4. 4
   その他at 170° C.
5. 5
   その他The product was obtained a clear oil

実験手順

The commercially available glycidol (0.17 mol, 11 ml) was added dropwise to stirred ethanolamine (1 eq, 1.4 mol, 84.3 ml) at 0° C. Once addition was complete the reaction was allowed to warm up to room temperature, while stirring overnight. The product was then distilled (Ethanolamine first distilled at 60° C. at 1 Torr, and the desired product at 170° C. at 1 Torr). The product was obtained a clear oil that cooled to a clear viscous syrup (0.122 mol, yield=72%).

出典