反応 #2275678

反応方程式

4-Nitro-N-(tert-octyl)benzamide

hydrogen

→

4-amino-N-(tert-octyl)benzamide

収率 76.1%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過After filtering
2. 2
   濃縮concentrating the solvent

実験手順

4-Nitro-N-(tert-octyl)benzamide (30 g, 0.108 mol) dissolved in 200 ml of ethyl acetate is hydrogenated for 1 hour 15 minutes at a temperature of 70-75° C. in a 500 ml hydrogenator in the presence of 4.8 g of 10% palladium-on-charcoal comprising 50% water as catalyst (hydrogen pressure: 8-10 bar). After filtering, concentrating the solvent and drying under vacuum, 20.4 g (Yield: 76%) of 4-amino-N-(tert-octyl)benzamide are obtained in the form of a pale yellow powder which is used as is in the following stage.

出典