反応 #2271674

反応方程式

3-(4-piperidinyl)-1H-indazole

1-[4-(4-bromobutoxy]-3-methoxyphenyl]ethanone

K2CO3

acetonitrile

→

1-[4-[4- [4-(1H-indazol-3-yl)-1-piperidinyl]-butoxy]-3-methoxyphenyl]ethanone

溶媒

water

反応条件

後処理

1. 1
   温度refluxed for 6 hours
2. 2
   その他the resulting yellow solid that formed
3. 3
   その他was collected in afford 5.3 g of product
4. 4
   その他The compound was recrystallized from acetonitrile

実験手順

A mixture of 3-(4-piperidinyl)-1H-indazole (3.2 g, 16 mmol, 1-[4-(4-bromobutoxy]-3-methoxyphenyl]ethanone (5.0 g, 16 mmol). K2CO3 (2.2 g) and acetonitrile (100 ml) was stirred and refluxed for 6 hours. The reaction was poured into water, and the resulting yellow solid that formed was collected in afford 5.3 g of product. The compound was recrystallized from acetonitrile and then from ethyl acetate to yield 3.0 g (45%) of a slightly yellow solid of 1-[4-[4- [4-(1H-indazol-3-yl)-1-piperidinyl]-butoxy]-3-methoxyphenyl]ethanone, m.p.=133°-135° C.

出典