反応 #2271672

反応方程式

K2CO3

3-(2-methoxyphenoxy)propyl chloride

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

fumaric acid

→

6-fluoro-3-[1-[3-(2-methoxyphenoxy)-propyl)-4-piperidinyl]-1,2-benzisoxazole fumarate

溶媒

acetonitrile

ethanol

反応条件

後処理

1. 1
   その他At the end of the reaction
2. 2
   その他the solvent-was removed
3. 3
   workup.DISSOLUTIONthe solids were dissolved into dichloromethane (100 ml)
4. 4
   洗浄The solution was washed with water and brine
5. 5
   乾燥dried over MgSO4
6. 6
   その他prepared in the same fashion (using 0.5 g of starting material)
7. 7
   その他The combined material was purified by flash chromatography on a silica gel column (49 g, eluted with 0.5% diethylamine: 1% methanol:98.5% dichloromethane, 1 L)
8. 8
   workup.ADDITIONThe fractions containing the pure product
9. 9
   濃縮concentrated down to a light oil (3.68 g)

実験手順

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole (2.45 g: 11.1 mmol). K2CO3 (2.0 g), and 3-(2-methoxyphenoxy)propyl chloride (3.5 g, 17.4 mmol) in acetonitrile (40 ml) was heated at 90° C. for 4 hours. At the end of the reaction, the solvent-was removed, and the solids were dissolved into dichloromethane (100 ml). The solution was washed with water and brine, then dried over MgSO4. The crude material from the solution was combined with 1.2 g of crude material prepared in the same fashion (using 0.5 g of starting material). The combined material was purified by flash chromatography on a silica gel column (49 g, eluted with 0.5% diethylamine: 1% methanol:98.5% dichloromethane, 1 L). The fractions containing the pure product were pooled and concentrated down to a light oil (3.68 g). This oil was treated with fumaric acid (1.14 g, 9.8 mmol) in ethanol (13 ml). The 6-fluoro-3-[1-[3-(2-methoxyphenoxy)-propyl)-4-piperidinyl]-1,2-benzisoxazole fumarate crystals obtained weighed 4.01 g (60%), m.p.=169°-170° C.

出典