反応 #2271669

反応方程式

3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

K2CO3

1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone

dimethyl formamide

→

beige solid

収率 94.7%

1-[4-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperidinyl]butoxy]-3-methoxyphenyl]ethanone

収率 94.7%

溶媒

water

反応条件

後処理

1. 1
   抽出was extracted with ethyl acetate
2. 2
   洗浄The ethyl acetate was washed (water)
3. 3
   乾燥dried (MgSO4)
4. 4
   濃縮the solvent concentrated

実験手順

A mixture of 3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (4.3 g, 18 mmol). K2CO3 (5.5 g, 40 mmol), and 1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone (5.5 g, 18 mmol), and dimethyl formamide (60 ml) was stirred and heated at 75° C. for 16 hours. The reaction was poured into water and was extracted with ethyl acetate. The ethyl acetate was washed (water), dried (MgSO4), and the solvent concentrated to afford 7.2 g of a beige solid. Recrystallization (twice) from ethyl alcohol yielded 3.3 g (43%) or 1-[4-[4-[4-(1,2-benzisoxazol-3-yl) )-1-piperidinyl]butoxy]-3-methoxyphenyl]ethanone, m.p.=99°-101° C.

出典