反応 #2267089

ord-f8c00701ed064db694c0e69151198392

反応方程式

CC(C)NC(C)C
Diisopropylamine
C=C1C(=O)O[C@H]2C[C@]3(C)O[C@H]3[C@@H]3O[C@@H]3C3=C[C@@H](OC3=O)[C@H]12
mikanolide
→
CC(C)N(CC1C(=O)OC2CC3(C)OC3C3OC3C3=CC(OC3=O)C21)C(C)C
product
収率 25.5%
CC(C)N(CC1C(=O)OC2CC3(C)OC3C3OC3C3=CC(OC3=O)C21)C(C)C
12-diisopropylaminomethyl-7-methyl-3.6,10,15-tetraoxapentacyclo[12.2.1.02,4.05,7.09,13]heptadec-1(17)-ene-11,16-dione
収率 25.5%

反応物

CC(C)NC(C)C
Diisopropylamine
C=C1C(=O)O[C@H]2C[C@]3(C)O[C@H]3[C@@H]3O[C@@H]3C3=C[C@@H](OC3=O)[C@H]12
mikanolide

試薬

なし

溶媒

CC(C)=O
acetone

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他the solvent is eliminated by evaporation under reduced pressure
  2. 2
    ろ過filtered
  3. 3
    その他dried under vacuum

実験手順

Diisopropylamine (500 μmol; 70 μl) is added to a solution of mikanolide (100 μmol; 29 mg) in acetone (1 ml). The reaction mass is stirred for 30 minutes at ambient temperature then the solvent is eliminated by evaporation under reduced pressure. The residue is taken up in ether, filtered and dried under vacuum. 10 mg of product is obtained in the form of a white powder.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06887869B2uspto-grants-2005_05