反応 #2267082

反応方程式

compound 14

6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

acetone

→

desired product

収率 82.0%

3-Acetylamino-4-methoxy-6-(4-nitrobenzoyl)-phenylacetone

収率 82.0%

溶媒

H2SO4

反応条件

後処理

1. 1
   抽出The solution was extracted with ethyl acetate three times
2. 2
   洗浄The combined organic phase was washed with brine
3. 3
   乾燥by drying over Na2SO4
4. 4
   その他Removal of the solvent

実験手順

To a solution of compound 14 (0.375 g, 1.05 mmol) in 30 ml of acetone was added 3 ml of CrO3 in 35% H2SO4 at 0° C. The resulted solution was stirred another 2 h at same temperature. Ice water was added. The solution was extracted with ethyl acetate three times. The combined organic phase was washed with brine, followed by drying over Na2SO4. Removal of the solvent afforded the desired product in the yield of 82%. 1HNMR(CDCl3): 8.5-7.8 (m, 6H), 6.8 (s, 1H), 4.08 (s, 2H), 3.8 (s, 3H), 2.24 (s, 3H), 2.21 (s, 3H).

出典