反応 #2267075

反応方程式

compound 13

1-(3-Acetylamino-4-methoxyphenyl)-2-propyl Alcohol

4-nitrobenzaldehyde

→

product 14

収率 66.0%

6-Acetylamino-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

収率 66.0%

溶媒

HCl

1,4-dioxane

反応条件

後処理

1. 1
   温度After refluxing for 5 hours
2. 2
   その他the solvent was removed under reduced pressure
3. 3
   洗浄The residue was washed with cold ethanol three times
4. 4
   その他dried

実験手順

To a solution of compound 13 (0.23 g, 1.03 mmol) in 15 ml of HCl solution in 1,4-dioxane was added 4-nitrobenzaldehyde (0.16 g, 1.06 mmol) in one portion. After refluxing for 5 hours, the solvent was removed under reduced pressure. The residue was washed with cold ethanol three times, and dried to give the product 14 (0.21 g, 66%).

出典