反応 #2267065

反応方程式

toluene

toluene

Dimethyl sulfoxide

5-azacytidine

5-azacytidine

DMSO

→

DMSO Toluene

反応条件

後処理

1. 1
   その他preheated to approximately 90° C., in separate 100-mL beakers
2. 2
   workup.DISSOLUTIONto dissolve to a clear solution
3. 3
   その他preheated to approximately 50° C.
4. 4
   workup.ADDITIONwas added to the solution
5. 5
   ろ過The product was collected by vacuum filtration as white crystals
6. 6
   その他to air dry

実験手順

Dimethyl sulfoxide (DMSO) was used as the primary solvent to solubilize Form I of 5-azacytidine and toluene was used as the co-solvent as follows. Approximately 250 mg of 5-azacytidine was dissolved with approximately 5 mL of DMSO, preheated to approximately 90° C., in separate 100-mL beakers. The solids were allowed to dissolve to a clear solution. Approximately 45 mL of toluene, preheated to approximately 50° C., was added to the solution and the resultant solution was mixed. The solution was covered and allowed to equilibrate at ambient conditions. The product was collected by vacuum filtration as white crystals using a Buchner funnel. The collected product was allowed to air dry.

出典