反応 #2263

反応方程式

p-chlorobenzoylpropionic acid

nitric acid

→

4-chloro-3-nitrobenzoylpropionic acid

反応条件

後処理

1. 1
   その他slowly portionwise at 0° C
2. 2
   workup.ADDITIONAfter the addition
3. 3
   ろ過the resulting white solid was suction filtered
4. 4
   洗浄washed with water until the pH of the washing liquids
5. 5
   その他dried
6. 6
   その他to yield 3-(4-chloro-3-nitrobenzoyl)propionic

実験手順

To fuming nitric acid (150 ml) was added p-chlorobenzoylpropionic acid (20.0 g), slowly portionwise at 0° C. After the addition was completed the resulting mixture was stirred at 0° C. for 30 minutes and the resulting white solid was suction filtered and washed with water until the pH of the washing liquids was neutral, then dried to yield 3-(4-chloro-3-nitrobenzoyl)propionic add as a white solid (13.0 g).

出典