反応 #2254204

反応方程式

2-[4-(4-fluorophenyl)oxan-4-yl]acetonitrile

LAH

→

2-[4-(4-fluorophenyl)oxan-4-yl]ethan-1-amine

溶媒

ether

反応条件

後処理

1. 1
   その他After 2 h the reaction was quenched with 1 ml H2O, 0.1 ml 15% NaOH
2. 2
   抽出The reaction mixture was extracted with Et2O (3×20 ml)
3. 3
   その他dried over NA2SO4
4. 4
   濃縮concentrated

実験手順

To a solution of 2-[4-(4-fluorophenyl)oxan-4-yl]acetonitrile (450 mg, 2.05 mmol) in anhydrous ether (15 ml) at 0° C. was added dropwise LAH (1.0 M in Et2O, 4.1 ml, 4.11 mmol). After 2 h the reaction was quenched with 1 ml H2O, 0.1 ml 15% NaOH and then 1 ml H2O. The reaction mixture was extracted with Et2O (3×20 ml), dried over NA2SO4 and concentrated to give 2-[4-(4-fluorophenyl)oxan-4-yl]ethan-1-amine as an yellow oil, which used without further purification (450 mg, 94%, m/z: 223.1 [M+H]+ observed).

出典