反応 #2254199

ord-209d9e9339364d4db7de1f3c96ee0a96

反応方程式

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

反応物

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride

試薬

なし

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.ADDITIONmixed thoroughly (i.e.
  2. 2
    workup.STIRRINGthe mixture was again homogenized
  3. 3
    workup.ADDITIONby addition of a suitable acid
  4. 4
    workup.ADDITIONThe solution is then poured onto a sheet
  5. 5
    その他dried in a heated oven

実験手順

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09044475B2uspto-grants-2015_06