反応 #2254171

反応方程式

sodium borohydride

ethanol

Ethyl 7-hydroxychromen-4-one-2-carboxylate

calcium chloride

Sodium borohydride

→

2-methoxy-7-hydroxy-4H-chromen-4-one

反応条件

後処理

1. 1
   温度again cooled
2. 2
   workup.STIRRINGThe mixture is stirred overnight at RT

実験手順

Ethyl 7-hydroxychromen-4-one-2-carboxylate (2 g, 8.538 mmol) and granulated and dried calcium chloride (1 g, 9.01 mmol) are initially introduced, and ethanol (absolute, 40 ml) is added. Sodium borohydride (1.33 g, 35.157 mmol) is subsequently added in portions with ice cooling. The reaction mixture is stirred at RT for 2 hours, then again cooled using an ice bath, and sodium borohydride (0.45 g, 11.895 mmol) is again added. The mixture is stirred overnight at RT.

出典