反応 #2254169

ord-458eca3c21d8400f9dcbc45757647934

反応方程式

Cl
hydrochloric acid
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
ClCCl
Methylene chloride
O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone

反応物

Cl
hydrochloric acid
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
ClCCl
Methylene chloride
—
hydrochloride salt
O=C([O-])[O-].[Na+].[Na+]
sodium carbonate

試薬

なし

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    抽出to extract the formed oxycodone free base
  2. 2
    乾燥The obtained organic layer was dried over sodium sulfate and methylene chloride
  3. 3
    その他was evaporated
  4. 4
    その他evaporator
  5. 5
    その他The obtained oxycodone free base was purified by crystallization

実験手順

The free base of oxycodone was prepared from its hydrochloride salt by the following method: Oxycodone hydrochloride was dissolved in water and sodium carbonate was added in the amount required to neutralize hydrochloric acid. Methylene chloride was added in order to extract the formed oxycodone free base. The obtained organic layer was dried over sodium sulfate and methylene chloride was evaporated using rotary evaporator. The obtained oxycodone free base was purified by crystallization.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09044398B2uspto-grants-2015_06