反応 #2254156

反応方程式

2-amino-3-bromo-5-chlorobenzoic acid

phosgene

→

title compound

収率 114.2%

8-Bromo-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

収率 114.2%

溶媒

dioxane

反応条件

後処理

1. 1
   濃縮concentrated in vacuo
2. 2
   その他The resulting solid was crushed
3. 3
   その他further dried in vacuo

実験手順

To a solution of 2-amino-3-bromo-5-chlorobenzoic acid (10.0 g, 39.9 mmol) in dioxane (170 mL) was added phosgene (20% in toluene, 42.0 mL, 79.9 mmol) over a period of 15 min. The reaction was stirred at room temperature for 48 h and then concentrated in vacuo. The resulting solid was crushed and further dried in vacuo to yield the title compound (12.6 g, 114%), which was used in the following step without further purification.

出典