反応 #2254

反応方程式

N-(3-chloro-phenyl)-4-(4-pyridyl)-2-pyrimidineamine

m-chloroperbenzoic acid

→

N-(3-chloro-phenyl)-4-(N-oxido4-pyridyl)-2-pyrimidineamine

溶媒

methylene chloride

反応条件

後処理

1. 1
   濃縮Concentration and crystallisation (acetic acid) of the residue

実験手順

10 g (35.4 mmol) of N-(3-chloro-phenyl)-4-(4-pyridyl)-2-pyrimidineamine and 11.1 g (35.4 mmol) of m-chloroperbenzoic acid are stirred for 5 h at RT in 500 ml of methylene chloride. Concentration and crystallisation (acetic acid) of the residue give N-(3-chloro-phenyl)-4-(N-oxido4-pyridyl)-2-pyrimidineamine; m.p. 274°-275°, Rf =0.6 (methylene chloride:methanol=9:1).

出典