反応 #2252

反応方程式

3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one

3-trifluoromethylphenyl-guanidine nitrate

sodium hydroxide

→

N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine

溶媒

2-propanol

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   洗浄is washed with 2-propanol and water
3. 3
   その他dried at 50° under HV

実験手順

150 mg (0.71 mmol) of 3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one are suspended in 1.5 ml of 2-propanol. 190 mg (0.712 mmol) of 3-trifluoromethylphenyl-guanidine nitrate and 31 mg (0.783 mmol) of sodium hydroxide are added and the reaction mixture is stirred for 18 h under RF. It is then cooled to RT and filtered, and the material retained on the filter is washed with 2-propanol and water and dried at 50° under HV to give N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine;

出典