反応 #2250

反応方程式

4-acetyl-2-chloro-pyridine

dimethylformamide diethylacetal

→

3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one

反応条件

後処理

1. 1
   温度Cooling to 0°
2. 2
   ろ過filtering
3. 3
   その他drying at 60° under HV

実験手順

16.2 g (104.2 mmol) of 4-acetyl-2-chloro-pyridine are stirred at 110° with 116 ml of dimethylformamide diethylacetal for 1 h. Cooling to 0°, filtering and drying at 60° under HV give 3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one; 1H-NMR (dimethyl sulfoxide): 2.98 (3H,s), 3.2 (3H,s), 5.9 (1H,d), 7.8 (3H,m), 8.5 (1H

出典