反応 #2245

反応方程式

3-(4-pyridinylamino)-1,2-benzisoxazole

methyl bromoacetate

→

title compound

収率 70.0%

[4-(3-Benzo[d]isoxazolylimino)-1-(4H)-pyridinyl]-acetic acid methyl ester hydrobromide

収率 70.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for one hour
3. 3
   ろ過the precipitated product was collected by filtration
4. 4
   洗浄The white solid was washed with diethyl ether
5. 5
   その他dried under vacuum

実験手順

A mixture of 3-(4-pyridinylamino)-1,2-benzisoxazole (0.9 g, 4.3 mmol) and methyl bromoacetate (0.44 mL, 1.1 eq) in acetonitrile (25 mL) was heated at reflux for one hour. The mixture was then allowed to cool to room temperature and the precipitated product was collected by filtration. The white solid was washed with diethyl ether and dried under vacuum to provide the title compound (1.1 g, 70%), mp 235-236° C.

出典