反応 #2231

反応方程式

urea

2-(4-dimethylaminophenyl)-2-hydroxy-1-phenylethanone

→

4-(4-dimethylaminophenyl)-2,3-dihydro-5-phenyl-1H-imidazol-2-one

溶媒

acetic acid

反応条件

後処理

1. 1
   温度the reaction was cooled to ambient temperature
2. 2
   ろ過The resulting solid was filtered
3. 3
   洗浄washed with ether
4. 4
   その他dried in vacuo

実験手順

To acetic acid (2 mL) was added urea (0.6 g, 10 mmol) and 2-(4-dimethylaminophenyl)-2-hydroxy-1-phenylethanone (2.6 g, 10 mmol). After stirring for 2 hours at 120° C., the reaction was cooled to ambient temperature. The resulting solid was filtered, washed with ether, and dried in vacuo to give 4-(4-dimethylaminophenyl)-2,3-dihydro-5-phenyl-1H-imidazol-2-one; NMR (CDCl3) 10.98 (s,2), 7.5 (m,4), 7.4 (m,5), 3.18 (s,6) ppm.

出典