反応 #220419

反応方程式

N-(3,5-difluorophenylacetyl)-L-alanine

N-(3,5-Difluorophenylacetyl)-L-alanine

3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

→

title compound

3-(N′-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

反応条件

後処理

1. 1
   その他The reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification

実験手順

Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (General Procedure 6-B), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.15 in 12% methanol/dichloromethane) and purification was by flash chromatography using 12% methanol/dichloromethane as the eluant.

出典