反応 #220296

反応方程式

Adenine

PMEA

adenine

ethylene carbonate

Magnesium Isopropoxide

→

9-(2-hydroxyethyl)adenine

収率 90.0%

溶媒

toluene

DMF

反応条件

後処理

1. 1
   温度The reaction was cooled to below 50° C.
2. 2
   温度The slurry was further cooled to 5° C. for 2 hours
3. 3
   ろ過filtered
4. 4
   洗浄rinsed with toluene (2×)
5. 5
   その他The wet solid was dried in vacuo at 65° C.

実験手順

Adenine to PMEA using Magnesium Isopropoxide. To a suspension of adenine (16.8 g, 0.124 mol) in DMF (41.9 ml) was added ethylene carbonate (12.1 g, 0.137 mol) and sodium hydroxide (.100 g, 0.0025 mol). The mixture was heated at 130° C. overnight. The reaction was cooled to below 50° C. and toluene (62.1 ml) was added. The slurry was further cooled to 5° C. for 2 hours, filtered, and rinsed with toluene (2×). The wet solid was dried in vacuo at 65° C. to yield 20.0 g (90%) of 9-(2-hydroxyethyl)adenine as an off-white solid. Mp: 238-240° C.

出典