反応 #2201163

反応方程式

3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone

N-(4-chloro-3-hydroxymethyl-phenyl)-guanidine nitrate

→

{2-Chloro-5-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenyl}-methanol

溶媒

MeCN

反応条件

実験手順

By condensation of 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and N-(4-chloro-3-hydroxymethyl-phenyl)-guanidine nitrate. Yellow solid. Mp 245-246° C. Anal. RP-HPLC: tR=14.6 min (10-70% MeCN, purity>95%). 1H-NMR (DMSO-D6) δ: 2.62 (s, 3H, CH3), 2.63 (s, 3H, CH3), 4.53 (d, 2H, J=5.5 Hz, CH2), 5.34 (m, 1H, OH), 7.08 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 7.29 (m, 1H, Ph-H), 7.73 (m, 1H, Ph-H), 7.94 (s, 1H, Ph-H), 8.51 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 9.78 (s, 1H, NH). MS (ESI+) m/z 347.11 [M+H]+ (C16H15ClN4OS requires 346.84).

出典