反応 #2201090

反応方程式

3-[5-p-tolyl-isoxazol-3-yl]-benzoic acid methyl ester

lithium hydroxide

→

title compound

3-(5-p-Tolyl-isoxazol-3-yl)-benzoic acid

溶媒

dioxane

反応条件

後処理

1. 1
   その他Then, the dioxane is removed in vacuo, 10 ml of water
2. 2
   workup.ADDITIONare added
3. 3
   ろ過The precipitate is filtered
4. 4
   その他dried

実験手順

In a 25 ml round flask, 330 mg (1.13 mmol) of 3-[5-p-tolyl-isoxazol-3-yl]-benzoic acid methyl ester is dissolved in 10 ml of dioxane and subsequently 1.69 ml of aqueous lithium hydroxide (1M, 1.69 mmol, 1.5 eq.) are added and the resulting solution stirred for 20 h at room temperature. Then, the dioxane is removed in vacuo, 10 ml of water are added and the pH adjusted to 2 with hydrochloric acid (1M). The precipitate is filtered and dried to yield the title compound as a white solid. Mass spectrum: m/z (M−H)+: 278.2

出典