反応 #2200592

反応方程式

hydrochloric acid

phenylpyruvic acid

oxalacetic acid

potassium hydroxide

→

4-phenylmethyl-4-hydroxy-2-ketoglutaric acid

収率 37.0%

溶媒

water

反応条件

後処理

1. 1
   その他to react at room temperature for 72 hours
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The organic layer was washed with saturated brine
4. 4
   乾燥dried on anhydrous magnesium sulfate, and condensed
5. 5
   その他to yield a residue
6. 6
   その他This was recrystallized from ethyl acetate and toluene

実験手順

To a solution of 13.8 g of potassium hydroxide (85% purity) dissolved in 25 ml of water were added 5.0 g (30.5 mmol) of phenylpyruvic acid and 12.1 g (91.4 mmol) of oxalacetic acid, and the mixture was allowed to react at room temperature for 72 hours. The reaction mixture was adjusted at pH 2.2 with conc. hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried on anhydrous magnesium sulfate, and condensed to yield a residue. This was recrystallized from ethyl acetate and toluene to yield 2.8 g (11.3 mmol) of 4-phenylmethyl-4-hydroxy-2-ketoglutaric acid as crystals.

出典