反応 #219886

反応方程式

(2S,2S)-2-benzyloxycarbonylamino-3-methyl-butyric acid 2-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-(2-methoxy carbonylamino-3,3-diphenyl-propionylamino)-hexyl ester

→

(2S,2S)-2-amino-3-methyl-butyric acid 2-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-(2-methoxycarbonylamino-3,3-diphenyl-propionylamino)-hexyl ester

収率 47.0%

溶媒

THF

反応条件

後処理

1. 1
   その他The mixture was reacted under hydrogen atmosphere overnight, at room temperature
2. 2
   ろ過The solution was filtered
3. 3
   洗浄the palladium on carbon was washed with THF (50 mL)
4. 4
   その他The solvent was evaporated
5. 5
   その他the residue (110 mg) was purified by flash chromatography
6. 6
   その他The clear oil was obtained in 47% yield (47 mg)

実験手順

To a stirred solution of (2S,2S)-2-benzyloxycarbonylamino-3-methyl-butyric acid 2-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-(2-methoxy carbonylamino-3,3-diphenyl-propionylamino)-hexyl ester (step C, 120 mg, 0.14 mmol) in anhydrous THF (8 mL), under nitrogen atmosphere, was added palladium 10% wt. on activated carbon (160 mg). The mixture was reacted under hydrogen atmosphere overnight, at room temperature. The solution was filtered and the palladium on carbon was washed with THF (50 mL). The solvent was evaporated and the residue (110 mg) was purified by flash chromatography using ethyl acetate as the eluent. The clear oil was obtained in 47% yield (47 mg).

出典