反応 #2195522

反応方程式

3-Methoxy-4-hydroxyphenylacetic acid propyl ester

3-methoxy-4-hydroxyphenylacetic acid propyl ester

K2CO3

2-chloro-N,N-diethylacetamide

→

dark yellow oil

収率 95.0%

[4-[(N,N-diethylcarbamoyl)methoxyl]-3-methoxyphenyl]acetic acid propyl ester

収率 95.0%

溶媒

acetone

反応条件

後処理

1. 1
   温度Under vigorous stirring, the suspension was warmed
2. 2
   温度After cooling to room temperature the reaction mixture
3. 3
   ろ過was filtered
4. 4
   その他the remaining solvent removed under reduced pressure

実験手順

3-Methoxy-4-hydroxyphenylacetic acid propyl ester (15-A) was dissolved in acetone. To the solution, 2 equivalents of K2CO3 were added, followed by 1.2 equivalent of 2-chloro-N,N-diethylacetamide. Under vigorous stirring, the suspension was warmed to reflux (60° C.) for ˜15 hours. After cooling to room temperature the reaction mixture was filtered and the remaining solvent removed under reduced pressure, giving a 95% yield of a dark yellow oil. The oily product was purified by silica column chromatography to produce the title compound.

出典