反応 #2195505

反応方程式

4-(tert-butyldimethylsilyloxy)dihydro-2H-pyran-2,6(3H)-dione

ammonium hydroxide

ammonia

→

title compound

4-(tert-Butyldimethylsilyloxy)piperidine-2,6-dione

溶媒

dioxane

反応条件

後処理

1. 1
   温度Cool in an ice/water bath
2. 2
   その他Cap the pressure tube
3. 3
   温度Cool the mixture
4. 4
   濃縮concentrate in vacuo
5. 5
   その他Purify the residue by silica gel chromatography

実験手順

Dissolve 4.1 mmol of 4-(tert-butyldimethylsilyloxy)dihydro-2H-pyran-2,6(3H)-dione (Nagao Y et al., Chem. Lett. 1990 9: 1503) in 10 mL of dioxane in a pressure tube. Cool in an ice/water bath, add 15 mL of saturated ammonium hydroxide and treat with gaseous ammonia via bubbler for about 10 min. Cap the pressure tube and heat in a 100° C. oil bath for 17 h. Cool the mixture and concentrate in vacuo. Purify the residue by silica gel chromatography using ethyl acetate/hexanes eluant to yield the title compound.

出典