反応 #2195504

ord-aa651554fc79487ea13c4e304829534e

反応方程式

Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid
Cl.NN1CC(F)(F)CC(F)(F)C1
product
Cl.NN1CC(F)(F)CC(F)(F)C1
3,3,5,5-Tetrafluoropiperidin-1-amine hydrochloride
Cc1c(C(=O)NN2CC(F)(F)CC(F)(F)C2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1.Cl
title compound
Cc1c(C(=O)NN2CC(F)(F)CC(F)(F)C2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1.Cl
5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3,3,5,5-tetrafluoropiperidin-1-yl)-1H-pyrazole-3-carboxamide hydrochloride

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Form the acid chloride from 2.0 mmol of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid and react it with 1.4 mmol of the product of Example 33 using the general procedure set forth in Example 39, to yield the title compound as a white solid.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07514068B2uspto-grants-2009_04