反応 #2195473

反応方程式

phenol

sodium hydride

HCl

→

Dibenzofuran

溶媒

DMSO

反応条件

後処理

1. 1
   抽出The aqueous phase is extracted with MTB ether
2. 2
   乾燥The organic phase is dried over sodium sulfate
3. 3
   その他evaporated
4. 4
   その他chromatographed on silica gel

実験手順

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

出典