反応 #219211

反応方程式

2-Fluorobenzoic acid

4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

EDC

HOBt

→

product

収率 19.1%

4-(2-Fluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

収率 19.1%

溶媒

DMSO

反応条件

後処理

1. 1
   その他purified by preparative LC/MS
2. 2
   その他Evaporation of product-containing fractions

実験手順

2-Fluorobenzoic acid (36 mg, 0.25 mmol) was added to a solution of 4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide (50 mg, 0.23 mmol), EDC (53 mg, 0.27 mmol) and HOBt (37 mg, 0.27 mmol) in DMSO (1 ml). The reaction mixture was stirred at room temperature for 24 hours and purified by preparative LC/MS. Evaporation of product-containing fractions yielded the product as a white solid (15 mg, 19%). (LC/MS: Rt 3.91, [M+H]+342.66).

出典