反応 #219111

反応方程式

(2-amino-5-methyl-phenyl)-(2-methoxy-phenyl)-methanone

2-aminothiazole

2-amino-5-methyl-benzoic acid

→

(2-Amino-5-methyl-phenyl)-(2-methoxy-phenyl)-methanone

収率 35.0%

1-[2-(2-methoxy-benzoyl)-4-methyl-phenyl]-3-thiazol-2-yl-urea

収率 72.0%

反応条件

実験手順

(2-Amino-5-methyl-phenyl)-(2-methoxy-phenyl)-methanone (843 g, 35%) was prepared from 2-amino-5-methyl-benzoic acid (1.51 g, 0.1 mol) following the general procedure S. 1-[2-(2-methoxy-benzoyl)-4-methyl-phenyl]-3-thiazol-2-yl-urea (132 mg, 72%) was prepared from (2-amino-5-methyl-phenyl)-(2-methoxy-phenyl)-methanone (121 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

出典