反応 #218842

反応方程式

4,7-Dihydroxy-5-methylcoumarin

dimethoxyacetaldehyde

→

title compound

収率 92.0%

3-(4,7-Dihydroxy-5-methyl-2-oxo-2H-chromene-3-yl)-7-hydroxy-9-methyl-2-methoxy-2,3-dihydro-4H-furo[3.2-c]chromene-4-one

収率 92.0%

溶媒

methanol

反応条件

後処理

1. 1
   温度the reaction mixture was refluxed for 5 hours
2. 2
   その他was precipitated
3. 3
   ろ過which was filtered off
4. 4
   洗浄washed with methanol
5. 5
   その他Obtained

実験手順

4,7-Dihydroxy-5-methylcoumarin (200 mg; 1.04 mmole) was dissolved in methanol (5 mL). A 60% aqueous dimethoxyacetaldehyde solution (792 μL; 8.7 mmole) was added and the reaction mixture was refluxed for 5 hours. By cooling to room temperature a white precipitate was precipitated, which was filtered off and washed with methanol. Obtained was the title compound in a 92% yield and of sufficient purity to be used in the next synthesis step:

出典