反応 #2188410

反応方程式

calcium hydroxide

L-Carnitine

butyric acid

water

→

L-carnitine calcium butyrate

収率 90.0%

溶媒

methanol

反応条件

後処理

1. 1
   workup.STIRRINGAfter continued stirring at room temperature for four hr
2. 2
   ろ過the solution was filtered
3. 3
   濃縮the filtrate was concentrated to dryness under vacuum at bath temperatures that
4. 4
   その他were less than about 70° C

実験手順

L-Carnitine (0.5 g, 0.003 mol) and butyric acid (0.54 g, 0.006 mol) were added to 5 mL of water and 1 mL of methanol. To the resulting solution was added calcium hydroxide (0.22 g, 0.003 mol). The resulting slurry clarified during 15 minutes of stirring at room temperature. After continued stirring at room temperature for four hr, the solution was filtered, and the filtrate was concentrated to dryness under vacuum at bath temperatures that were less than about 70° C. The solid, L-carnitine calcium butyrate, was obtained in greater than 90% yield and had a melting point of 97.6° C., with decomposition and evolution of trimethylamine. (The melting point of L-carnitine was 186-190° C. Butyric acid is a liquid.) The solid was not hygroscopic. The solid had no objectionable taste but had a somewhat bitter aftertaste. The 1H-NMR spectrum (FIG. 2) is consistent with the structure of the salt and shows the presence of L-carnitine and butyrate in a molar ratio of approximately 1:2. (Calcium is not detected by 1H-NMR.)

出典