反応 #2186203

反応方程式

4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde

(6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester

acetonitrile

piperidine

→

desired product

収率 23.4%

3-(6-Chloro-imidazo[1,2-a]pyridin-2-yl)-7-[4-(2-fluoro-ethyl)-piperazin-1-yl]-chromen-2-one

収率 23.4%

溶媒

benzene

反応条件

後処理

1. 1
   ろ過the precipitated material filtered
2. 2
   洗浄washed with diethyl ether
3. 3
   その他dried under high vacuum

実験手順

253 mg (1 mmol) 4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde and 450 mg (2 eq.) (6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester refluxed in 15 mL benzene and 7.5 mL acetonitrile in the presence of 0.395 mL (4 eq.) piperidine for 21 h. The reaction mixture is cooled to 0° C. and the precipitated material filtered, washed with diethyl ether and dried under high vacuum, yielding 100 mg (23%) desired product as a yellow solid. M.p.=265° C. (decomposition).

出典