反応 #2186192

反応方程式

3-Piperazin-1-yl-phenol

1-bromo-2-fluoroethane

→

desired product

収率 48.0%

3-[4-(2-Fluoro-ethyl)-piperazin-1 -yl]-phenol

収率 48.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他to reach room temperature
2. 2
   その他evaporated
3. 3
   その他the residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1)

実験手順

1 g (5.61 mmol) 3-Piperazin-1-yl-phenol and 0.5 mL (1.25 eq) 1-bromo-2-fluoroethane are stirred 20 h at 60° C. in 5 mL DMF, the reaction mixture allowed to reach room temperature and evaporated, and the residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1) to yield 600 mg (48%) of the desired product as a brown oil.

出典